Having exposed colour slides in 35mm and 6x6 for about 30 years on an amateur basis, without the aid of any spotmeter at all, I was kind of naive with respect to what should be the proper metering method for large format slides.
Sure, a first-time user of large format slides should be careful, taking into account the financial aspect, and read all good advice on how to see if the scene will fit within the brightness range of a colour slide, and eventually sacrifice part of the image but only after a careful analysis.
But in some cases, the image is just straightforward and easy. For example, since this image was not made on a single 4x5" sheet of slide but on a poor men's 6x12 on rollfilm (Fuji Provia 100F),
http://www.cijoint.fr/cj200901/cijY81lkoi.jpg
I simply used the incident light metering technique with my lunasix, and the good faithful instrument suggested that I should expose according to the sunny-16 rule.
What I did, with the additional correction of -1.5 stop due to the use of a centre filter.
Reasonable photographers would probably think that I had no chance to get a satisfying result, and surprisingly the image was seen and considered as acceptable by experts who only swear by the spot-meter... (I did not disclose to them what had been my metering method)
So my advice would be : to start with, choose an easy subject for which the sunny-16 rule gives the same exposure as your usual hand-held meter or 35 mm camera, and go for it...
Too bad ! This does not answer at all the initial question, if the subject is not an easy one...
Well more seriously, if taking pictures of monuments, when the stone is bright you are art risk of being overexposed in the walls, so you should think about it.
For example in France many monuments are built with the so-called Burgondy stone, quite bright with respect other stones, and you should really thing about keeping details in the stone, hence compensate and deliberately under-expose the scene. This kind of s'tone

cannot be the mid-tone, but it should not be over-exposed... the spotmeter analysis, then gives the proper answer.
Another with colour slides rule that I learned from the same experts is that you are allowed, say, 5-%10% of surface of the image to be grossly overexposed /sacrificed if it is not near the principal subject and it it does not attract the eye too much.
The typical example in abbeys is a picture of the inside of the cloister, you are allowed to sacrifice the small parts of the image of what is outside... or use a DSLR and the so-called HDR method if you realy want to get everything !
Or go for color negs or for the tri-color process on B&W film with a very broad dynamic range !
